Rationale for using essential phospholipids in chronic diseases of the liver: the dynamics of electric and viscoelastic parameters of erythrocytes

• Published in: Ėksperimental'nai͡a︡ i klinicheskai͡a︡ gastroėnterologii͡a no. 11; p. 46
• Main Authors: Kurilovich, S A, Kruchinina, M V, Gromov, A A, Generalov, V M, Bakirov, T S, Rikhter, T C, Semenov, D V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2010
• Subjects: Adjuvants, Immunologic - administration & dosage; Adjuvants, Immunologic - metabolism; Adult; Electric Impedance; Erythrocyte Deformability - drug effects; Erythrocyte Membrane - metabolism; Female; Hepatitis, Chronic - drug therapy; Hepatitis, Chronic - metabolism; Humans; Male; Middle Aged; Phosphatidylcholines - administration & dosage; Phosphatidylcholines - metabolism; Viscosity
• ISSN: 1682-8658

Under supervision there were 38 men (age from 36 till 57 years) with diffuse hepatic diseases (DHD) in stadia of hepatitis, 27--in dynamics of treatment of essential phospholipids. Is experimentally established: structure-functional erythrocyte characteristics by methods of dielectrophoresis, thin-layer chromatography correlate with lipid and phospholipid composition of red cell membranes. The low level of phospholipids in erythrocyte membranes and direction of changes in their fractional composition in the DHD is the basis for the use of essential phospholipids. Against the background of therapy noted a significant increase in amplitude of deformation, polarizability, capacity, speed of movement of red blood cells to the electrodes and lower levels of generalized indicators of viscosity, rigidity, electrical conductivity, index of aggregation and destruction.