Skin metastasis: an unusual localization from laryngeal carcinoma

• Published in: Kulak burun boğaz ihtisas dergisi Vol. 12; no. 3-4; p. 103
• Main Authors: Aydin, Omer, Ustündağ, Emre, Boyaci, Zerrin, Müezzinoğlu, Bahar
• Format: Journal Article
• Language: English
• Published: Turkey 2004
• Subjects: Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - radiotherapy; Carcinoma, Squamous Cell - secondary; Carcinoma, Squamous Cell - surgery; Diagnosis, Differential; Fatal Outcome; Hand - pathology; Humans; Laryngeal Neoplasms - diagnosis; Laryngeal Neoplasms - pathology; Laryngeal Neoplasms - radiotherapy; Laryngeal Neoplasms - surgery; Male; Middle Aged; Neoplasm Metastasis; Skin Neoplasms - diagnosis; Skin Neoplasms - radiotherapy; Skin Neoplasms - secondary; Skin Neoplasms - surgery
• ISSN: 1300-7475

Skin metastasis from laryngeal carcinoma is rare and indicates a poor prognosis. A case of laryngeal carcinoma with unusual metastasis to the skin of the hand is reported. The patient underwent total laryngectomy, left radical neck dissection, and right functional neck dissection. After the operation, the patient received radiotherapy. In the postoperative 18th month, a mass was observed in the left hand. It was found to be a metastatic tumor from laryngeal carcinoma, histopathologically as well as immunohistochemically. Metastatic potential in malignant neoplasms is generally correlated with reduced cellular adhesiveness. We investigated the expression of the vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and E-cadherin. Interestingly, the immunohistochemical expression characteristics of such an aggressive tumor were not positive.