Bone quality changes in diabetes

Diabetes-related bone fragility has recently drawn many researchers' attention. Diabetes would affect bone remodeling by various mechanisms, including deficiency of insulin actions, increased accumulation of advanced glycation end products and microangiopathy. The combination of poor bone quali...

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Bibliographic Details
Published in:	Clinical calcium Vol. 18; no. 5; p. 600
Main Authors:	Wada, Seiki, Kamiya, Sadahiro, Fukawa, Takeshi
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-05-2008
Subjects:	Animals Bone and Bones - metabolism Bone Density Bone Remodeling Collagen Type I - metabolism Diabetes Mellitus - metabolism Glycation End Products, Advanced - metabolism Humans Insulin - deficiency
Online Access:	Get more information
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Summary:	Diabetes-related bone fragility has recently drawn many researchers' attention. Diabetes would affect bone remodeling by various mechanisms, including deficiency of insulin actions, increased accumulation of advanced glycation end products and microangiopathy. The combination of poor bone quality of microstructure and nanoarchitecture (type I collagen and non-collageous proteins) would reduce bone strength. Bone mineral density is the best predictor for fractures of primary osteoporosis, but presumably not for type 2 diabetes. Quality changes of diabetic bone, therefore, should be more thoroughly studied.
ISSN:	0917-5857