Treatment results of chemotherapy with S-1 for head and neck cancer

A study of chemotherapy treatment with S-1 in patients with head and neck cancer was conducted in 20 patients with residual tumor after primary chemoradiotherapy, or recurrent tumors. Treatment courses consisted of oral administration of S-1 at a dose of 80 to 120 mg/day depending on the body surfac...

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Bibliographic Details
Published in:	Gan to kagaku ryoho Vol. 36; no. 2; p. 237
Main Authors:	Shirasaki, Takashi, Maruya, Shin-ichiro, Namba, Atsushi, Matsubara, Atsushi, Shinkawa, Hideichi
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-02-2009
Subjects:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Drug Combinations Female Head and Neck Neoplasms - diagnostic imaging Head and Neck Neoplasms - drug therapy Humans Male Middle Aged Oxonic Acid - adverse effects Oxonic Acid - therapeutic use Tegafur - adverse effects Tegafur - therapeutic use Tomography, X-Ray Computed Treatment Outcome
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Summary:	A study of chemotherapy treatment with S-1 in patients with head and neck cancer was conducted in 20 patients with residual tumor after primary chemoradiotherapy, or recurrent tumors. Treatment courses consisted of oral administration of S-1 at a dose of 80 to 120 mg/day depending on the body surface area for 14 consecutive day followed by a 7- day rest period. The response rate in patients with residual tumors after primary chemoradiotherapy was 55.6%(5/9). In patients with recurrent tumors, the response rate was 0%(0/11), however, median survival time was 534.5 days. Therefore, S-1 seemed to be useful for the treatment of patients with head and neck cancer from the point of QOL.
ISSN:	0385-0684