Use of low molecular weight heparin (Clexane) together with selective COX-2 inhibitor (Dynastat--once or twice per day)

• Published in: Akusherstvo i ginekologiia Vol. 44; no. 5; p. 31
• Main Authors: Tablov, B, Ruseva, A, Tablov, V, Popov, I, Stoĭkov, S
• Format: Journal Article
• Language: Bulgarian
• Published: Bulgaria 2005
• Subjects: Anticoagulants - administration & dosage; Anticoagulants - therapeutic use; Cyclooxygenase Inhibitors - administration & dosage; Cyclooxygenase Inhibitors - therapeutic use; Drug Administration Schedule; Drug Therapy, Combination; Enoxaparin - administration & dosage; Enoxaparin - therapeutic use; Female; Follow-Up Studies; Heparin, Low-Molecular-Weight - administration & dosage; Heparin, Low-Molecular-Weight - therapeutic use; Humans; Hysterectomy; Isoxazoles - administration & dosage; Isoxazoles - therapeutic use; Laparoscopy; Postoperative Complications - prevention & control; Treatment Outcome
• ISSN: 0324-0959

A follow-up of forty women was carried out. The patients having endured a gynecological operation (laparohysterectomy) were divided into two groups: group A--treated with Dynastat (40 mg/24h) and group B--treated with Dynastat (80mg/24h) which was combined in both groups with Clexane. The hematological and hemostatic parameters were evaluated during the early postoperative period--the first 24 hours. The women were followed until they were discharged from hospital. No significant changes of these laboratory parameters were noticed and the clinical stability of the patients in both groups was unaffected. The results showed that Dynastat/Clexane combination could be applied in the clinical practice as it proved great extend of safety for usage after gynecological operations.