Examination and treatment for dilutional thrombocytopenia

• Published in: Rinsho byori. The Japanese journal of clinical pathology Vol. 53; no. 7; p. 654
• Main Authors: Ishida, Akaru, Handa, Makoto
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-07-2005
• Subjects: Humans; Platelet Count; Platelet Transfusion; Thrombocytopenia - diagnosis; Thrombocytopenia - etiology; Thrombocytopenia - therapy; Transfusion Reaction
• ISSN: 0047-1860

Massive transfusion is defined as transfusion of more than total blood volume within 24 hours. There are several adverse effects associated with massive transfusion, and dilutional thrombocytopenia is known as one of the major adverse effects. Dilutional thrombocytopenia is caused by platelet loss out of the body and platelet dilution with replaced red cells and crystalloids. Volume of blood loss or replaced volume is a good indicator of dilutional thrombocytopenia, and previous reports suggest that severe thrombocytopenia doesn't occur before replaced volume surpasses over one hundred and fifty percent of total blood volume. Recently, an automated blood cell counter has spread and platelet count is available in a short time, even at night. To treat the patient with dilutional thrombocytopenia, platelet count is very helpful to decide when to start platelet transfusion. When platelet count decreases as low as 50,000/mm3, platelet transfusion should be considered. Nowadays, dilutional thrombocytopenia is less frequent complications of massive transfusion than before, because platelet transfusion tends to be performed before platelet count fall to the critical point. Thus, exceeded platelet transfusion might become another problem after massive transfusion.