Methods of evaluating the effect of pharmacological drugs on aging and life span in mice

Methods of evaluating the effect of pharmacological drugs on aging and life span in mice

The methodology of testing anti-aging drugs in laboratory mice is presented. It includes the selection of mouse strain, sex, age at start of treatment, housing conditions, design of the long-term study, some noninvasive methods of assessment, pathology examination, and statistical treatment of the r...

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Bibliographic Details
Published in:Methods in molecular biology (Clifton, N.J.) Vol. 371; p. 227
Main Authors: Anisimov, Vladimir N, Popovich, Irina G, Zabezhinski, Mark A
Format: Journal Article
Language:English
Published: United States 2007
Subjects:
Aging - drug effects
Animals
Drug Evaluation, Preclinical
Humans
Mice
Models, Biological
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Description
Summary:The methodology of testing anti-aging drugs in laboratory mice is presented. It includes the selection of mouse strain, sex, age at start of treatment, housing conditions, design of the long-term study, some noninvasive methods of assessment, pathology examination, and statistical treatment of the results.
ISSN:1064-3745
DOI:10.1385/1-59745-361-7:227