The contribution of proangiogenic factors to the progression of malignant disease: role of vascular endothelial growth factor and its receptors

• Published in: Surgical oncology clinics of North America Vol. 10; no. 2; p. 339
• Main Authors: Neufeld, G, Kessler, O, Vadasz, Z, Gluzman-Poltorak, Z
• Format: Journal Article
• Language: English
• Published: United States 01-04-2001
• Subjects: Cell Hypoxia - genetics; Cell Hypoxia - physiology; Disease Progression; Endothelial Growth Factors - antagonists & inhibitors; Endothelial Growth Factors - physiology; Humans; Lymphokines - antagonists & inhibitors; Lymphokines - physiology; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - physiopathology; Neoplasm Metastasis - genetics; Neoplasm Metastasis - physiopathology; Neoplasm Metastasis - prevention & control; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - physiopathology; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors
• ISSN: 1055-3207
• DOI: 10.1016/s1055-3207(18)30069-3

Vascular endothelial growth factor is a major inducer of angiogenesis and a vascular permeability inducing factor. Its expression is upregulated in many types of tumors and it is thought to be a major inducer of tumor angiogenesis. This article focuses on the role of vascular endothelial growth factor in tumor progression and on current efforts aimed at the inhibition of tumor progression through the inhibition of vascular endothelial growth factor activity.