Supplementation with antioxidants in the treatment of Graves' disease: the effect on the extracellular antioxidative parameters

• Published in: Acta pharmaceutica (Zagreb, Croatia) Vol. 54; no. 2; pp. 79 - 89
• Main Authors: Bacić Vrca, Vesna, Skreb, Franjo, Cepelak, Ivana, Mayer, Ljiljana
• Format: Journal Article
• Language: English
• Published: Croatia 01-06-2004
• Subjects: Adult; Antioxidants - metabolism; Antioxidants - pharmacology; Antioxidants - therapeutic use; Dietary Supplements; Extracellular Fluid - drug effects; Extracellular Fluid - metabolism; Female; Graves Disease - blood; Graves Disease - drug therapy; Humans; Male; Middle Aged
• ISSN: 1330-0075

In this study, the effect of supplementation with a fixed combination of antioxidants (vitamins C and E, beta-carotene and selenium) on concentrations of antioxidative parameters in serum was monitored. Measurements were performed prior to the commencement of therapy and after 30 and 60 days in patients with Graves' disease treated with methimazole. Patients who received extra supplementation with antioxidants (group A, n = 29) attained euthyroidism faster than the patients treated only with methimazole (group B, n = 28). Statistically significant differences were achieved after supplementation with antioxidants for all investigated parameters (uric acid, transferrin, ferritin), except TAS and glucose. Nevertheless, due to the fact that all measured parameters remained within the range of referent values, they may not be proposed as reliable indicators of the level of oxidative stress in Graves' disease.