The role of Matrix Metaloproteinases in the progression of periodontitis, and the use of specific inhibitors to these enzymes in the treatment of the periodontal disease

Matrix Metaloproteinases (MMPs) play a crucial role in the pathogenesis of the periodontal disease. This group of enzymes can degrade most of the proteins that compose the extracellular matrix. Recently a new concept of treatment, the "host modulating therapy" (HMT) was developed. The rati...

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Bibliographic Details
Published in:	Refu'at ha-peh veha-shinayim (1993) Vol. 20; no. 2; p. 38
Main Authors:	Nasatzky, E, Rubinstein, Y, Goultschin, J, Schwartz, Z
Format:	Journal Article
Language:	Hebrew
Published:	Israel 01-04-2003
Subjects:	Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Dental Scaling Disease Progression Humans Inflammation Mediators - physiology Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases - physiology Minocycline - administration & dosage Minocycline - therapeutic use Nitric Oxide - physiology Periodontitis - drug therapy Periodontitis - enzymology Periodontitis - physiopathology Prostaglandins - physiology Tissue Inhibitor of Metalloproteinases - therapeutic use Tumor Necrosis Factor-alpha - physiology
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