Implications of a mathematical model for the role of lymphocytes with different lifespans in the recovery from tolerance

An extension of the mathematical model of immunological tolerance including two categories of B and T helper cells, each having a different lifespan, is presented. The simulated recovery from tolerance is compared with experimental data on B and T helper cell tolerance to human gamma globulin (HGG)...

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Bibliographic Details
Published in:	Folia biologica Vol. 33; no. 5; p. 356
Main Authors:	Dolezal, J, Hraba, T
Format:	Journal Article
Language:	English
Published:	Czech Republic 1987
Subjects:	Animals B-Lymphocytes - cytology B-Lymphocytes - immunology gamma-Globulins - immunology Humans Immune Tolerance Kinetics Mathematics Mice Models, Biological T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - immunology Time Factors
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Summary:	An extension of the mathematical model of immunological tolerance including two categories of B and T helper cells, each having a different lifespan, is presented. The simulated recovery from tolerance is compared with experimental data on B and T helper cell tolerance to human gamma globulin (HGG) induced in adult mice. The performed simulation runs suggest the conclusion that in this case it seems impossible to incorporate a high ratio of both, long-lived B cells and/or short-lived T helper cells, if good agreement with the available experimental data should be preserved.
ISSN:	0015-5500