Potential antiatherosclerotic agents. 3. Substituted benzoic and non benzoic acid analogues of cetaben

• Published in: Journal of medicinal chemistry Vol. 26; no. 10; pp. 1393 - 1411
• Main Authors: Albright, J D, DeVries, V G, Du, M T, Largis, E E, Miner, T G, Reich, M F, Shepherd, R G
• Format: Journal Article
• Language: English
• Published: United States 01-10-1983
• Subjects: 4-Aminobenzoic Acid - chemical synthesis; 4-Aminobenzoic Acid - pharmacology; 4-Aminobenzoic Acid - therapeutic use; Aminobenzoates - chemical synthesis; Animals; Arteriosclerosis - drug therapy; Benzoates - therapeutic use; Drug Evaluation, Preclinical; Hyperlipidemias - drug therapy; Male; Methods; para-Aminobenzoates; Rats; Rats, Inbred Strains; Sterol O-Acyltransferase - antagonists & inhibitors; Sterols - blood; Structure-Activity Relationship; Triglycerides - blood
• ISSN: 0022-2623
• DOI: 10.1021/jm00364a010

The synthesis of a series of analogues in which the carboxylic acid group of cetaben is replaced by carboxylate ester, carboxamide, or a variety of other substituent groups is described. Also reported are the syntheses of analogues in which the phenyl ring of cetaben is either modified by the presence of additional substituents or replaced entirely by another moiety. Structure-activity relationships of these compounds both as hypolipidemic agents and as inhibitors of the enzyme fatty acyl-CoA:cholesterol acyltransferase (ACAT) are discussed. Analogue syntheses designed to produce compounds that would be better absorbed orally than cetaben failed to yield any congeners of enhanced biological activity. In contrast, analogue syntheses directed toward non carboxylic acids of similar acidity to cetaben produced a very active class of sulfonamides.