Alpha-interferon therapy for lymphoproliferative disorders developing in two children following bone marrow transplants

Two children developed lymphoproliferative processes following marrow transplantation. One of the two lymphoproliferative processes was documented to be Epstein-Barr virus (EBV)-associated. Both children received an extended course of alpha-interferon and gammaglobulin and responded with the disappe...

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Bibliographic Details
Published in:	Journal of biological response modifiers Vol. 8; no. 6; p. 603
Main Authors:	Trigg, M E, de Alarcon, P, Rumelhart, S, Holida, M, Giller, R
Format:	Journal Article
Language:	English
Published:	United States 01-12-1989
Subjects:	Anemia, Aplastic - surgery Bone Marrow Transplantation - adverse effects Child Child, Preschool Female gamma-Globulins - therapeutic use Graft vs Host Disease - prevention & control Herpesvirus 4, Human Humans Interferon Type I - therapeutic use Lymphoproliferative Disorders - etiology Lymphoproliferative Disorders - therapy Male Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery Tumor Virus Infections - complications Tumor Virus Infections - therapy
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Summary:	Two children developed lymphoproliferative processes following marrow transplantation. One of the two lymphoproliferative processes was documented to be Epstein-Barr virus (EBV)-associated. Both children received an extended course of alpha-interferon and gammaglobulin and responded with the disappearance of the lymphoproliferative process. Side effects from the alpha-interferon were minimal. Previous experience with EBV-associated lymphoproliferative processes following marrow transplantation have been usually fatal. This report further substantiates that alpha-interferon has a role in the treatment of EBV-associated lymphoproliferative processes following marrow transplantation.
ISSN:	0732-6580