New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients

We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype dis...

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Bibliographic Details
Published in:	Acta Universitatis Carolinae. Medica Vol. 36; no. 1-4; p. 102
Main Authors:	Devoto, M, De Benedetti, L, Ronchetto, P, Romano, L, Romeo, G, Tsui, L C, Dean, M, Collins, F, Seia, M, Piceni Sereni, L
Format:	Journal Article
Language:	English
Published:	Czech Republic 1990
Subjects:	Cystic Fibrosis - complications Cystic Fibrosis - genetics Exocrine Pancreatic Insufficiency - complications Genetic Carrier Screening Genetic Markers Haplotypes Humans Linkage Disequilibrium Molecular Probes Polymorphism, Restriction Fragment Length
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Summary:	We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.
ISSN:	0001-7116