Human leucocyte antigen DNA typing in Singaporean Chinese patients with Graves' disease

Human leucocyte antigen DNA typing in Singaporean Chinese patients with Graves' disease

Human Leucocyte Antigen (HLA) A, B, C, DR, DQ and DP locus alleles in 35 Chinese patients with Graves' disease and 80 controls were typed for using serological and DNA polymerase chain reaction/sequence specific oligonucleotide (PCR/SSO) methods. B46 was found to be strongly associated with mal...

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Bibliographic Details
Published in:Annals of the Academy of Medicine, Singapore Vol. 22; no. 4; p. 576
Main Authors: Chan, S H, Lin, Y N, Wee, G B, Ren, E C, Lui, K F, Cheah, J S
Format: Journal Article
Language:English
Published: Singapore 01-07-1993
Subjects:
Adult
Alleles
China - ethnology
Cross-Cultural Comparison
DNA - genetics
Gene Frequency - genetics
Graves Disease - genetics
Histocompatibility Antigens Class I - genetics
Histocompatibility Antigens Class II - genetics
Humans
Male
Polymerase Chain Reaction
Risk Factors
Singapore
China
Singapore
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Summary:Human Leucocyte Antigen (HLA) A, B, C, DR, DQ and DP locus alleles in 35 Chinese patients with Graves' disease and 80 controls were typed for using serological and DNA polymerase chain reaction/sequence specific oligonucleotide (PCR/SSO) methods. B46 was found to be strongly associated with male patients (p = 0.0002; RR = 8.2, 95% confidence interval 2.1-32.2). In HLA class 1 alleles, besides B46, the frequencies of A2 and Cw1 were increased and A24 and B63 decreased in patients compared to controls. In HLA class 2 alleles, the frequencies of DRB1*1602, *0301, *1405, DRB5*02, DQB1*0502 were increased and DRB1*1501, DQB1*0301 decreased in patients.
ISSN:0304-4602