Effects of two antihistamines on chloroquine and histamine induced weal and flare in healthy African volunteers

This study investigated the effects of single doses of clemastine (2mg orally), mepyramine (2 micrograms intradermally) and placebo on weal and flare caused by intradermal chloroquine 2.5mg and histamine 2 micrograms in 11 healthy black subjects who experienced generalised pruritus with oral chloroq...

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Bibliographic Details
Published in:	African journal of medicine and medical sciences Vol. 23; no. 2; p. 139
Main Authors:	Abila, B, Ezeamuzie, I C, Igbigbi, P S, Ambakederemo, A W, Asomugha, L
Format:	Journal Article
Language:	English
Published:	Nigeria 01-06-1994
Subjects:	Administration, Oral Adolescent Adult African Continental Ancestry Group Analysis of Variance Chloroquine - adverse effects Clemastine - therapeutic use Cross-Over Studies Histamine - adverse effects Histamine - physiology Humans Injections, Intradermal Male Pruritus - chemically induced Pruritus - drug therapy Pruritus - physiopathology Pyrilamine - therapeutic use Single-Blind Method
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Summary:	This study investigated the effects of single doses of clemastine (2mg orally), mepyramine (2 micrograms intradermally) and placebo on weal and flare caused by intradermal chloroquine 2.5mg and histamine 2 micrograms in 11 healthy black subjects who experienced generalised pruritus with oral chloroquine. Compared with placebo, both antihistamines caused significant reductions in histamine-induced weal and flare. By contrast, chloroquine-induced weal and flare were not significantly altered by clemastine or mepyramine when compared with placebo. It is concluded that histamine is unlikely to be the main mediator of chloroquine-induced weal and flare. These findings are in consonance with the lack of significant effect of antihistamines on chloroquine-induced generalised pruritus.
ISSN:	0309-3913