Treatment of IUD related menorrhagia by indomethacin

Indomethacin, prostaglandin synthetase inhibitor was tested in 9 women wearing a lippes loop IUD. These women suffered from excessive bleeding with a mean menstrual blood loss of more than 100 ml. The effect was studied by quantifying menstrual blood loss in a double blind 4 periods crossover study....

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Bibliographic Details
Published in:	Clinical and experimental obstetrics & gynecology Vol. 11; no. 4; p. 120
Main Authors:	Yarkoni, S, Anteby, S O
Format:	Journal Article
Language:	English
Published:	Canada 1984
Subjects:	Adult Cyclooxygenase Inhibitors Female Humans Indomethacin - therapeutic use Intrauterine Devices - adverse effects Menorrhagia - drug therapy Menorrhagia - etiology Iud, Unmedicated Iud > side effects Organic Chemicals Biology Contraceptive Methods > side effects Family Planning Research Methodology Endocrine System Menorrhagia Diseases Prostaglandins, Synthetic Menstruation Disorders Contraception > side effects Prostaglandins Treatment Carboxylic Acids Clinical Research Ingredients And Chemicals Physiology
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Summary:	Indomethacin, prostaglandin synthetase inhibitor was tested in 9 women wearing a lippes loop IUD. These women suffered from excessive bleeding with a mean menstrual blood loss of more than 100 ml. The effect was studied by quantifying menstrual blood loss in a double blind 4 periods crossover study. The mean percentage reduction during treatment was of 57 percent. No significant placebo effect was observed. The effect of indomethacin support the contention that IUD's associated menorrhagia, is connected to an abnormal prostaglandin synthetase in the endometrium.
ISSN:	0390-6663