The histopathological comparison of the results of the intra-arterial injections of propofol and thiopentone in rabbits

• Published in: Materia medica Polona. Polish journal of medicine and pharmacy Vol. 24; no. 1; p. 41
• Main Authors: Babacan, A, Akçabay, M, Uluoğlu, O, Ozkoçak, I, Karadenizli, Y
• Format: Journal Article
• Language: English
• Published: Poland 01-01-1992
• Subjects: Animals; Ear, External - drug effects; Ear, External - pathology; Injections, Intra-Arterial; Male; Propofol - administration & dosage; Rabbits; Thiopental - administration & dosage
• ISSN: 0025-5246

The results of injections of propofol and thiopentone intra-arterially are compared in rabbits according to histopathological criteries. Thirteen New Zealand type rabbits are used. Two ml of 2.5% Thiopentone and 2 ml of 1% Propofol are administered to the rabbits under anesthesia. Three days after, their ears are amputated and sent to this pathological blind examination. In both groups, we saw neither a morphological change along the vessel walls nor significant bleeding. But between the groups there was a significant difference about oedema. Consequently, 2.5% thiopentone which is routinely used after intra-arterial administration, may be responsible of the gangrenous change but it is discussable and it makes significant oedema in animal models although propofol does not have this effect.