Enhanced lipid peroxidation in patients during coronary artery bypass grafting

Lipid peroxidation products were measured at various time intervals in 20 patients with coronary artery disease, who underwent coronary artery bypass graft (CABG) surgery. Post-operative blood lipid peroxides were found to be significantly higher (p < 0.001) than the preoperative value. Lipid per...

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Bibliographic Details
Published in:	Indian heart journal Vol. 45; no. 6; pp. 489 - 491
Main Authors:	Jayakumari, N, Kumari, K S, Ambikakumari, V, Nazer, Y, Singh, M P, Balakrishnan, K G, Iyer, K S
Format:	Journal Article
Language:	English
Published:	India 01-11-1993
Subjects:	Adult Aged Coronary Artery Bypass Coronary Disease - metabolism Coronary Disease - surgery Free Radicals Humans Lipid Peroxidation Lipid Peroxides - blood Male Middle Aged Myocardial Reperfusion Myocardial Reperfusion Injury - etiology
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Summary:	Lipid peroxidation products were measured at various time intervals in 20 patients with coronary artery disease, who underwent coronary artery bypass graft (CABG) surgery. Post-operative blood lipid peroxides were found to be significantly higher (p < 0.001) than the preoperative value. Lipid peroxides raised to a peak value of 46.42 +/- 12.86 n mol/g Alb at 5 min of reperfusion when compared to the basal value and afterwards the level declined to 41.02 +/- 7.09 at 2 hrs and remained in that level even at 24 hrs of reperfusion. This increase implies an enhancement in free radical mediated oxidation of membrane lipids during bypass surgery and thus provides evidence for free radical generation during myocardial reperfusion.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0019-4832