DNA ploidy pattern of flow cytometry as indicator of degrees of malignancy and prognosis in colorectal cancers

Cellular DNA content of primary colorectal cancers was measured by flow cytometry and investigated on clinico-pathological features to elucidate the relationship between DNA ploidy patterns and outcomes. IN 144 colorectal carcinomas, DNA diploid carcinomas accounted for 23% and DNA aneuploid carcino...

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Bibliographic Details
Published in:	Nihon rinshō Vol. 50; no. 10; p. 2419
Main Authors:	Seo, K, Yamamura, T, Hanai, A, Katayama, K
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-10-1992
Subjects:	Adult Aged Aged, 80 and over Colorectal Neoplasms - diagnosis Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology DNA, Neoplasm - analysis Female Flow Cytometry Humans Lymphatic Metastasis Male Middle Aged Neoplasm Invasiveness Neoplasm Metastasis Ploidies Prognosis Survival Rate
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Summary:	Cellular DNA content of primary colorectal cancers was measured by flow cytometry and investigated on clinico-pathological features to elucidate the relationship between DNA ploidy patterns and outcomes. IN 144 colorectal carcinomas, DNA diploid carcinomas accounted for 23% and DNA aneuploid carcinomas for 77%. NO significant difference was observed between DNA ploidy pattern and tumor differentiation, lymph node metastasis or lympangial invasion. DNA aneuploid tumor had a tendency to invade vein and to lead to hematogenic metastasis. Patients with DNA aneuploid tumor showed a significantly poor disease-free and overall survival rate. Significantly increased incidence of hematogenic recurrence was demonstrated in the DNA aneuploid cases. These results suggest that the DNA ploidy pattern of colorectal cancers may prove to be of prognostic value.
ISSN:	0047-1852