Activity of catecholamines inactivating enzymes in heart muscle during anoxic cardioplegia in cardiosurgical patients

On the model of anoxic cardioplegia in cardiosurgical patients the influence of anoxia on the activity of monoamine oxidase (MAO) and catechol-O-methyltransferase (COMPT) in right auricular tissue was studied. It was found out that the activity of COMT does not change during anoxia, the activity of...

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Bibliographic Details
Published in:	Zeitschrift fur experimentelle Chirurgie Vol. 8; no. 6; p. 379
Main Authors:	Barta, E, Kuzela, L, Kvetnanský, R, Siska, K, Babusíková, F, Torda, T
Format:	Journal Article
Language:	English
Published:	Germany 1975
Subjects:	Cardiac Output, Low - etiology Catechol O-Methyltransferase - metabolism Heart Arrest, Induced Humans Hypoxia - metabolism Monoamine Oxidase - metabolism Myocardium - enzymology Myocardium - metabolism Norepinephrine - metabolism Oxygen Consumption Time Factors
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Summary:	On the model of anoxic cardioplegia in cardiosurgical patients the influence of anoxia on the activity of monoamine oxidase (MAO) and catechol-O-methyltransferase (COMPT) in right auricular tissue was studied. It was found out that the activity of COMT does not change during anoxia, the activity of MAO considerably increases. With regard to catecholamines stimulating effect upon cardiac metabolism as well as to their calorigenic and oxygen wasting effect the raise of MAO activity may be regarded as favourable phenomenon, because the hastened degradation of released catecholamines at least to a certain degree diminishes the disproportion between oxygen supply and actual oxygen need of the heart and by means of that mitigates the anoxic damage of myocardium.
ISSN:	0323-5580