In vitro study of clonazepam diffusion kinetics from solutions or hydrophilic gel

In vitro study of clonazepam diffusion kinetics from solutions or hydrophilic gel

Preliminary studies were conducted to evaluate the influence of temperature, pH and ionic strength of the donor and receptor medium on the solubility, partition coefficient and diffusion rate of clonazepam across a lipophilic artificial membrane, in view of future setting up of transdermal formulati...

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Bibliographic Details
Published in:Pharmaceutica acta Helvetiae Vol. 65; no. 11; p. 298
Main Authors: Mura, P, Liguori, A, Bramanti, G, Corti, P, Murratzu, C, Celesti, L
Format: Journal Article
Language:English
Published: Switzerland 1990
Subjects:
Chemical Phenomena
Chemistry, Physical
Clonazepam - chemistry
Clonazepam - pharmacokinetics
Diffusion
Gels
Solutions
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Summary:Preliminary studies were conducted to evaluate the influence of temperature, pH and ionic strength of the donor and receptor medium on the solubility, partition coefficient and diffusion rate of clonazepam across a lipophilic artificial membrane, in view of future setting up of transdermal formulation of this drug. The in vitro release of clonazepam from a carbopol hydrogel was also investigated.
ISSN:0031-6865