Study of a Cohort of Patients With Cystic Fibrosis and Isolation of Scedosporium spp

• Published in: Archivos de bronconeumología (English ed.) Vol. 55; no. 11; pp. 559 - 564
• Main Authors: Erro Iribarren, Marta, Girón Moreno, Rosa María, Diab Cáceres, Layla, Pastor Sanz, María Teresa, Buendía Moreno, Buenaventura, Alarcón Cavero, Teresa, Granja Torrecillas, Silvia, Zurita Cruz, Nelly Daniela, Ancochea Bermúdez, Julio
• Format: Journal Article
• Language: English; Spanish
• Published: 01-11-2019
• ISSN: 1579-2129
• DOI: 10.1016/j.arbres.2019.02.018

INTRODUCTIONIn recent years an increase in the prevalence of colonization and infection by Scedosporium spp. in patients with cystic fibrosis (CF) has been observed. In this article, we study the frequency of isolation of Scedosporium spp. in an adult CF Unit, analyzing characteristics of the patients and predisposing factors. METHODSA retrospective observational study was conducted in 87 adult CF patients in whom the presence of positive culture for Scedosporium spp. was tested for a 5-year period (January 2012-July 2017). We recorded the following clinical variables: age, sex, body mass index, genotype, presence of pancreatic insufficiency, bacterial colonization, lung function, other complications, exacerbations and treatment, and the modified Bhalla score from the last high-resolution computed tomography. Results were analyzed with IBM SPSS Statistics Version 22.0 software. RESULTSScedosporium spp. was isolated in 25.3% of patients. In the bivariate analysis, these patients showed a higher rate of Pseudomonas aeruginosa infection, worse score in the Bhalla classification (highlighting the following items: bronchiectasis, mucus plugs and bronchial generations), a slight decrease in the lung diffusion capacity and more frequently received inhaled antibiotics. In the logistic regression multivariate analysis, only the bronchial generations item was significant. CONCLUSIONScedosporium spp. must be considered an emerging opportunistic pathogen in patients with CF whose clinical involvement, risk factors or need for treatment is unknown.