Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLa activation and function in mismatch repair

Eukaryotic MutLa (mammalian MLH1-PMS2 heterodimer; MLH1-PMS1 in yeast) functions in early steps of mismatch repair as a latent endonuclease that requires a mismatch, MutSa/β, and DNA-loaded proliferating cell nuclear antigen (PCNA) for activation. We show here that human PCNA and MutLa interact spec...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 19; p. 4930
Main Authors:	Genschel, Jochen, Kadyrova, Lyudmila Y, Iyer, Ravi R, Dahal, Basanta K, Kadyrov, Farid A, Modrich, Paul
Format:	Journal Article
Language:	English
Published:	Washington National Academy of Sciences 09-05-2017
Subjects:	Activation Adenosine triphosphatase Amino acid substitution Amino acids Antigens Deoxyribonucleic acid DNA Endonuclease Eukaryotes Genotype & phenotype In vitro methods and tests Mismatch repair MLH1 protein Mutation Proliferating cell nuclear antigen Repair Yeast
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