Desensitization to pirfenidone. Report of one case

We report a 68-year-old woman with a history of idiopathic pulmonary fibrosis, who had immediate skin reactions associated with the use of pirfenidone in two opportunities. In the evaluation by immunology, an allergy to pirfenidone was diagnosed. Given the urgent need for the drug, a desensitization...

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Bibliographic Details
Published in:	Revista medíca de Chile Vol. 149; no. 10; p. 1512
Main Authors:	Bastías O, Carla, Reyes C, Felipe, Rodriguez M, Karla, Díaz B, Ilennee
Format:	Journal Article
Language:	Spanish
Published:	Chile 01-10-2021
Subjects:	Aged Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Female Humans Idiopathic Pulmonary Fibrosis Pyridones - adverse effects
Online Access:	Get full text
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Summary:	We report a 68-year-old woman with a history of idiopathic pulmonary fibrosis, who had immediate skin reactions associated with the use of pirfenidone in two opportunities. In the evaluation by immunology, an allergy to pirfenidone was diagnosed. Given the urgent need for the drug, a desensitization procedure was started. The dose of the medication was increased progressively, previous premedication with cetirizine, ranitidine and montelukast. After this procedure the patient was able to tolerate the treatment with pirfenidone without cutaneous reactions.
ISSN:	0717-6163