Serous Tubal Intraepithelial Carcinoma After Neoadjuvant Chemotherapy: A Report of 2 Cases

• Published in: International journal of gynecological pathology
• Main Authors: Stroot, Iris A S, Smit, Leonie, de Bock, Geertruida H, Wagner, Marise M, Jalving, Mathilde, van Kempen, Léon C L T, Bart, Joost, Mourits, Marian J E
• Format: Journal Article
• Language: English
• Published: United States 22-08-2024
• ISSN: 1538-7151; 1538-7151
• DOI: 10.1097/PGP.0000000000001045

Serous tubal intraepithelial carcinoma (STIC) is regarded as the origin of most high-grade serous carcinomas (HGSC). After a diagnosis of isolated STIC, risk of developing HGSC is substantial. Since surveillance cannot detect HGSC in time to cure the disease, there is no consensus on the optimal treatment after a diagnosis of isolated STIC, but chemotherapy is considered one of the possible strategies. In this case report, we describe 2 women with advanced-stage HGSC treated with 3 cycles of neoadjuvant chemotherapy followed by interval debulking surgery. In both women, histopathological examination showed a complete histopathological tumor response, but a vital STIC was found in both cases. The 2 cases presented here indicate that STICs may not respond to chemotherapy. Further research focused on the underlying biology and chemosensitivity of STIC, as well as the effectiveness of treatment to prevent HGSC in case of isolated STIC, is needed.