鬼箭羽 추출물의 염증성세포활성물질 억제효과

• Published in: 동의생리병리학회지 Vol. 23; no. 2; pp. 368 - 373
• Main Authors: 김대현(Dae Hyeon Kim), 김병진(Byung Jin Kim), 박경배(Kyung Bae Park), 이주성(Ju Sung Lee), 성강경(Kang Keyng Sung), 박성주(Sung Joo Park)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01-04-2009
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

The purpose of this study was to investigate the anti-inflammatory effects of water extract from Euonymus alatus (Thunb.) Sieb. (EAS) on the RAW 264.7 cells. To evaluate of anti-inflammatory of EAS, we examined the cytokine productions on lipopolysaccharide (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms using Western blot. EAS reduced LPS-induced production of nitric oxide (NO), interleukin (IL)-1b, IL-6, IL-10 and tumor necrosis factor-a (TNF-a) in RAW 264.7 cells. EAS inhibited the activation of mitogen-activated protein kinases (MAPKs) such as p38, extracelluar signal-regulated kinase (ERK 1/2) and c-Jun NH2-terminal kinase (JNK) but not of inhibitory kappa B a (Ik-Ba) degradation in the LPS-stimulated RAW 264.7 cells. In conclusion, EAS down-regulated LPS-induced NO and cytokines production, which could provide a clinical basis. KCI Citation Count: 0