Cytotoxic germacranolide sesquiterpene lactones from Carpesium triste var. manshuricum

Cytotoxic germacranolide sesquiterpene lactones from Carpesium triste var. manshuricum

Four known germacranolide sesquiterpene lactones, 2alpha,5-epoxy-5,10-dihydroxy-6alpha-angeloyloxy-9beta-isobutyloxy-germacran-8alpha,12-olide (1), 2alpha,5-epoxy-5,10-dihydroxy-6alpha,9beta-diangeloyloxy-germacran-8alpha,12-olide (2, divaricin B), 2alpha,5-epoxy-5,10-dihydroxy-6alpha-angeloyloxy-9b...

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Bibliographic Details
Published in:Archives of pharmacal research Vol. 30; no. 5; pp. 556 - 560
Main Authors: Kim, Mi-Ran, Hwang, Bang Yeon, Jeong, Eun-Sook, Lee, Yong-Moon, Yoo, Hwan-Soo, Chung, Youn-Bok, Hong, Jin Tae, Moon, Dong-Cheul
Format: Journal Article
Language:English
Published: 대한약학회 01-05-2007
Subjects:
약학
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Summary:Four known germacranolide sesquiterpene lactones, 2alpha,5-epoxy-5,10-dihydroxy-6alpha-angeloyloxy-9beta-isobutyloxy-germacran-8alpha,12-olide (1), 2alpha,5-epoxy-5,10-dihydroxy-6alpha,9beta-diangeloyloxy-germacran-8alpha,12-olide (2, divaricin B), 2alpha,5-epoxy-5,10-dihydroxy-6alpha-angeloyloxy-9beta-(2-methylbutyloxy)-germacran-8alpha,12-olide (3) and 2alpha,5-epoxy-5,10-dihydroxy-6alpha-angeloyloxy-9beta-(3-methylbutyloxy)-germacran-8alpha,12-olide (4), were isolated from the chloroform-soluble fraction of the whole plants of Carpesium triste var. manshuricum. Their chemical structures were determined using spectroscopic methods, including 2D-NMR. All the isolates showed significant cytotoxicities (ED50 value: 4.3-16.8 microM) against five human tumor cell lines; A549, SK-OV-3, SK-MEL-2, XF498 and HCT15.
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G704-000010.2007.30.5.014
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02977648