Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 mRNA Vaccine

Some persons who have recovered from Covid-19 have antibodies to the spike protein of SARS-CoV-2. In 43 such persons who had received a first mRNA vaccine dose, high levels of neutralizing antispike antibodies were produced — in many cases even higher than after a second dose in 67 persons without b...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 384; no. 14; pp. 1372 - 1374
Main Authors:	Krammer, Florian, Srivastava, Komal, Alshammary, Hala, Amoako, Angela A, Awawda, Mahmoud H, Beach, Katherine F, Bermúdez-González, Maria C, Bielak, Dominika A, Carreño, Juan M, Chernet, Rachel L, Eaker, Lily Q, Ferreri, Emily D, Floda, Daniel L, Gleason, Charles R, Hamburger, Joshua Z, Jiang, Kaijun, Kleiner, Giulio, Jurczyszak, Denise, Matthews, Julia C, Mendez, Wanni A, Nabeel, Ismail, Mulder, Lubbertus C.F, Raskin, Ariel J, Russo, Kayla T, Salimbangon, Ashley-Beathrese T, Saksena, Miti, Shin, Amber S, Singh, Gagandeep, Sominsky, Levy A, Stadlbauer, Daniel, Wajnberg, Ania, Simon, Viviana
Format:	Journal Article
Language:	English
Published:	Boston Massachusetts Medical Society 08-04-2021
Subjects:	Age Antibodies Coronaviruses COVID-19 Influenza mRNA mRNA vaccines Pain Polls & surveys Severe acute respiratory syndrome coronavirus 2 Spike protein Vaccination
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Summary:	Some persons who have recovered from Covid-19 have antibodies to the spike protein of SARS-CoV-2. In 43 such persons who had received a first mRNA vaccine dose, high levels of neutralizing antispike antibodies were produced — in many cases even higher than after a second dose in 67 persons without baseline antibodies to the virus. Systemic reactions were more common in those seropositive before vaccination.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMc2101667