Stabilizing Effect of β-Cyclodextrin on Limaprost, a PGE1 Derivative, in Limaprost Alfadex Tablets (Opalmon(R)) in Highly Humid Conditions

Stabilization against humidity of Limaprost (a prostaglandin E1 derivative), which is currently marketed as Opalmon(R), was undertaken using β-cyclodextrin (β-CD). Aqueous solutions of Limaprost alfadex/dextran 40 were lyophilized with and without β-CD. Limaprost alfadex lyophilized with β-CD was mo...

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Bibliographic Details

Published in:	Chemical and Pharmaceutical Bulletin Vol. 62; no. 8; pp. 786 - 792
Main Authors:	Yasuo Inouea, Noboru Sekiyaa, Kazunori Katayamaa, Shoji Narutakia, Masanobu Yamamotoa, Daisuke Ioharab, Fumitoshi Hirayamab, Kaneto Uekamac
Format:	Journal Article
Language:	Japanese
Published:	Pharmaceutical Society of Japan 01-08-2014
Online Access:	Get full text
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