에탄올 음용으로 유도된 발기부전 동물모델에 대한 구기자 추출물의 개선효과

• Published in: 동의생리병리학회지 Vol. 27; no. 5; pp. 625 - 630
• Main Authors: 정세희(Se Hee Jung), 김정훈(Jung Hoon Kim), 오홍근(Hong Geun Oh), 신은혜(Eun Hye Shin), 이봉근(Bong Gun Lee), 박상훈(Sang Hoon Park), 문대인(Dae In Moon), 박영미(Young Mi Park), 한주희(Ju Hee Han), 한종현(Jong Hyun Han), 박광현(Kwang Hyun Park), 박종상(Jong Sang Park), 한승준(Seung Jun Han), 류도곤(Do Gon Ryu), 권강범(Gang Beom Gwon), 이영래(Young Rae Lee), 김옥진(Ok Jin Kim), 이학용(Hak Yong Lee)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2013
• Subjects: 한의학; nitric oxide; cyclic guanosine monophosphate; Lycii fructus extracts; erectile dysfunction
• DOI: 10.15188/kjopp.2013.10.27.5.625
• EISSN: 2288-2529; 2283-2529
• ISSN: 1738-7698

Erectile dysfunction (ED) is a highly prevalent disorder that affects millions of men worldwide. ED is now considered an early manifestation of atherosclerosis, and consequently, a precursor of systemic vascular disease. Lycii fructus extracts (LFE) were administered for 4 weeks to assess the improving effects on ED. Animals were divided into one normal group and four LFE-treated groups (0, 0.3, 0.6, and 1.2 g/kg). We induced ED in the study animals by oral administration of 20% ethanol instead of water everyday for 4 weeks. This study was designed to investigate the effects of LFE on the mRNA levels of inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) expression; NO levels of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP); blood profile; and erectile response of the corpus cavernosum of the rat penis. The libido of the LFE-administered male rats was higher than that of the ethanol control group. The erectile response of the corpus cavernosum was restored after LFE administration, to a level similar to the normal group. In addition, the iNOS in the corpus cavernosum of the male rats administered LFE decreased. In contrast, compared to the control group, LFE-administered male rats showed increased eNOS, NO and cGMP levels in the corpus cavernosum. These results indicate that LFE effectively restored ethanol-induced ED in male rats.