호두 속껍질 없는 것과 있는 것의 물 추출물 투여가 생쥐의 비장세포 및 대식세포의 활성에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 20; no. 5; pp. 1217 - 1222
• Main Authors: 은재순(Jae Soon Eun), 박훈(Hoon Park), 이경아(Kyung A Lee), 권진(Jin Kwon), 안문생(Mun Saeng Ahn)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2006
• Subjects: 한의학; Juglandis Semen; macrophages; splenocytes
• ISSN: 1738-7698; 2288-2529; 2283-2529

The purpose of this research was to investigate the effects of the administration of Juglandis Semen without inner cortex (JE) or with inner cortex (JEIC) on activity of splenocytes and peritoneal macrophages in BALB/C mice. JE (300 mg/kg, p.o.) did not affect the cell viability of T- and B-lymphocytes in murine splenocytes, but JEIC (300mg/kg, p.o.) increased the cell viability of T- and B-lymphocytes. Furthermore, JE decreased the population of B220$^+$ cells in splenocytes, but JEIC enhanced the population of Thyl$^+$ cells. Also, JEIC enhanced the population of splenic CD4$^+$ cells. JE decreased the production of nitric oxide and the phagocytic activity of peritoneal macrophages, but JEIC increased the production of nitric oxide and the phagocytic activity of peritoneal macrophages. These results suggest that JEIC is more potent than JE against the immune response induced by splenocytes and macrophages.