Extracellular matrixes and neuroinflammation

• Published in: BMB reports Vol. 53; no. 10; pp. 491 - 499
• Main Authors: Jang, Dong Gil, Sim, Hyo Jung, Song, Eun Kyung, Kwon, Taejoon, Park, Tae Joo
• Format: Journal Article
• Language: Korean
• Published: 생화학분자생물학회 31-10-2020
• Subjects: DAMP; Extracellular matrix; Neurodegenerative disease and ECM; Neuroinflammation; Neuronal ECM; Neuronal ECM; Extracellular matrix; Neuroinflammation; Neurodegenerative disease and ECM; DAMP
• ISSN: 1976-6696; 1976-670X

The extracellular matrix is a critical component of every human tissue. ECM not only functions as a structural component but also regulates a variety of cellular processes such as cell migration, differentiation, proliferation, and cell death. In addition, current studies suggest that ECM is critical for the pathophysiology of various human diseases. ECM is composed of diverse components including several proteins and polysaccharide chains such as chondroitin sulfate, heparan sulfate, and hyaluronic acid. Each component of ECM exerts its own functions in cellular and pathophysiological processes. One of the interesting recent findings is that ECM is involved in inflammatory responses in various human tissues. In this review, we summarized the known functions of ECM in neuroinflamma-tion after acute injury and chronic inflammatory diseases of the central nerve systems. [BMB Reports 2020; 53(10): 491-499]