New Production of 5-Bromotoluhydroquinone and 4-O-Methyltoluhydroquinone from the Marine-Derived Fungus Dothideomycete sp

• Published in: Journal of microbiology and biotechnology Vol. 22; no. 1; pp. 80 - 83
• Main Authors: Leutou, Alain S, Yun, Keum-Ja, Choi, Hong-Dae, Kang, Jung-Sook, Son, Byeng-Wha
• Format: Journal Article
• Language: Korean
• Published: 한국미생물생명공학회 30-01-2012
• Subjects: 4-Omethyltoluhydroquinone; 5-Bromotoluhydroquinone; Dothideomycete sp; gentisyl alcohol; toluhydroquinone; gentisyl alcohol; toluhydroquinone; Dothideomycete sp; 4-O-methyltoluhydroquinone; 5-Bromotoluhydroquinone
• ISSN: 1017-7825; 1738-8872

The addition of NaBr to the fermentation medium of a marine isolate of the fungus Dothideomycete sp. resulted in induced production of two toluhydroquinone derivatives, 5- bromotoluhydroquinone (1) and 4-O-methyltoluhydroquinone (2), and two known compounds, toluhydroquinone (3) and gentisyl alcohol (4). The structures of 1 and 2 were assigned through the spectroscopic data analyses. Compounds 1-4 showed a potent antibacterial activity against the methicillinresistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA) with MIC (minimum inhibitory concentration) values of 6.2, 12.5, 6.2, and 12.5 μg/ml, respectively. Compounds 1-4 also exhibited a moderate radical scavenging activity against 1,1-diphenyl-2- picrylhydrazyl (DPPH) with IC50 values of 11.0, 17.0, 12.0, and 7.0 μM, respectively, which were more active than the positive control, L-ascorbic acid (IC50, 20.0 μM).