Biallelic Inactivation of hMLH1 by Epigenetic Gene Silencing, a Novel Mechanism Causing Human MSI Cancers

Mutations of DNA mismatch repair genes, including the hMLH1 gene, have been linked to human colon and other cancers in which defective DNA repair is evidenced by the associated instability of DNA microsatellite sequences (MSI). Germ-line hMLH1 mutations are causally associated with inherited MSI col...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 95; no. 15; pp. 8698 - 8702
Main Authors:	Veigl, Martina L., Kasturi, Lakshmi, Olechnowicz, Joseph, Ma, AiHong, Lutterbaugh, James D., Periyasamy, Sumudra, Li, Guo-Min, Drummond, James, Modrich, Paul L., Sedwick, W. David, Markowitz, Sanford D.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences of the United States of America 21-07-1998 National Acad Sciences National Academy of Sciences The National Academy of Sciences
Subjects:	Adaptor Proteins, Signal Transducing Alleles Azacitidine - pharmacology Base Sequence Biological Sciences Cancer Carrier Proteins Cell lines Colorectal cancer Deoxyribonucleic acid DNA DNA Methylation DNA Primers Epigenetics Genes Humans Methylation Microsatellite Repeats Mutation MutL Protein Homolog 1 Neoplasm Proteins - genetics Neoplasms - genetics Nuclear Proteins Promoter regions Promoter Regions, Genetic Protein synthesis Tumor cell line Tumors
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