Pediatric nasopharyngeal cancer with repeated oligometastases involving the bone, liver and distant lymph nodes who achieved cure after radiotherapy

• Published in: Nagoya journal of medical science Vol. 82; no. 1; pp. 135 - 141
• Main Authors: Ohguri, Takayuki, Kakinouchi, Sho, Imada, Hajime, Matsuyama, Atsuji, Yahara, Katsuya, Nakahara, Sota, Hohchi, Nobusuke, Suzuki, Hideaki, Korogi, Yukunori
• Format: Journal Article
• Language: English
• Published: Japan Nagoya University 01-02-2020
• Subjects: Adolescent; Antineoplastic Agents - administration & dosage; Bone Neoplasms - radiotherapy; Bone Neoplasms - secondary; Carboplatin - administration & dosage; Case Report; Chemoradiotherapy; Disease-Free Survival; Dose Fractionation, Radiation; Female; Humans; Liver Neoplasms - radiotherapy; Liver Neoplasms - secondary; Lymphatic Metastasis; Nasopharyngeal Carcinoma - radiotherapy; Nasopharyngeal Carcinoma - secondary; Nasopharyngeal Neoplasms - pathology; Nasopharyngeal Neoplasms - radiotherapy; Time Factors; radiotherapy; head and neck; bone metastasis; oligometastases; nasopharyngeal
• ISSN: 0027-7622; 2186-3326
• DOI: 10.18999/nagjms.82.1.135

Systemic chemotherapy is a standard treatment for Stage IVc nasopharyngeal carcinoma (NPC). Stage IVc NPC patients with oligometastases have a better prognosis, and local therapy has an important role in further development of the disease. However, the efficacy of local therapy to the metastases in patients with multiple-site and/or multiple-organ metastases is limited due to the aggressive behavior of the tumor. We report a NPC case in a pediatric patient with repeated oligometastases involving the bone, liver and distant lymph nodes who achieved 10-year disease free status after initial chemotherapy and radiotherapy to all the metastases. This very rare case demonstrated that radiotherapy to oligometastatic lesions have a potential to cure repeated oligometastases which involved multiple-organ metastases in a pediatric NPC with stage IVc.