EXPERIMENTAL AND CLINICAL STUDIES ON CEFTIZOXIME IN THE FIELD OF PLASTIC SURGERY

• Published in: CHEMOTHERAPY Vol. 28; no. Supplement5; pp. 478 - 486
• Main Authors: OKIMOTO, YUICHIRO, OHURA, TAKEHIKO, YOSHIDA, TETSUNORI, IIDA, KAZUNORI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 01-01-1980
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.28.Supplement5_478

Ceftizoxime, a new antimicrobial agent, was evaluated experimentally and clinically. The results obtained were as follows. 1) Serum and skin concentrations of ceftizoxime in rabbits The subjects consisted of adult rabbits ranging from 2.5 kg to 3.5kg in weight. Twenty mg/kg of ceftizoxime were admitted intravenously in one shot. The highest serum concentration was 41.0μg/ml at 10 minutes after injection, and the value at 4 hours after injection was 0.9μg/ml. The skin concentration reached peak at 10 minutes after injection indicated 35.8μg/g, and the level declined and was negligible by 4 hours. 2) Serum and skin concentrations of ceftizoxime. n adult patients The subjects consisted of 3 adult patients who were operated “full thickness skin graft” under general anesthesia. One gram of ceftizoxime was injected intravenously in one shot. The peak concentration in the serum was 58.8μg/ml at 10 minutes after injection and showed 28.5μg/ml 30 minutes after injection. The skin concentration one hour after injection was 21.0μg/g. These specimens were obtained from excess parts of removal full thickness skin for grafting. 3) Clinical studies Five patients with wound infection who were within normal limits on laboratory data, were treated with 1.0 g of ceftizoxime twice a day intramuscularly or intravenously. Causative organisms were disappeared in two cases, and diminished in one case. No side effect was observed in these cases.