Effects of Verapamil and BAY K 8644 on the Hypoxic Contraction of the Isolated Human Pulmonary Artery

• Published in: The Tohoku Journal of Experimental Medicine Vol. 157; no. 1; pp. 81 - 82
• Main Authors: OHE, MASATOSHI, OGATA, MASAHIKO, SHIRATO, KUNIO, TAKISHIMA, TAMOTSU
• Format: Journal Article
• Language: English
• Published: Japan Tohoku University Medical Press 1989
• Subjects: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology; calcium channel; human; Humans; hypoxic pulmonary vasoconstriction; In Vitro Techniques; Muscle Contraction - drug effects; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - physiology; Oxygen Consumption; Pulmonary Artery - drug effects; Pulmonary Artery - innervation; Pulmonary Artery - physiology; Verapamil - pharmacology
• ISSN: 0040-8727; 1349-3329
• DOI: 10.1620/tjem.157.81

OHE, M., OGATA, M., SHIRATO, K. and TAKISHIMA, T. Effects of Verapamil and BAY K 8644 on the Hypoxic Contraction of the Isolated Human Pulmonary Artery. Tohoku J. Exp. Med., 1989, 157 (1), 81-82 - To examine the effect of hypoxia on the human pulmonary artery (HPA), HPA segments (2mm, o.d.) were suspended and changes in isometric force with hypoxia (PO2=44±3mmHg, mean±S.E.) were measured. HPA contracted with hypoxia and the tension developed with 15min of hypoxia was 127±36 (mean±S.E.) mg. Verapamil at 10-6M inhibited and 10-6M BAY K 8644 enhanced the hypoxic response by 47± 10% (p<0.01) and 396±106% (p<0.05), respectively, compared with preceding values. These results show that activation of voltage-dependent Ca2+ channels also plays an important role in the mechanism of hypoxic pulmonary vasoconstriction in man