Enantioselective Synthesis of the Novel Chiral Sulfoxide Derivative as a Glycogen Synthase Kinase 3β Inhibitor

Glycogen synthase kinase 3β (GSK-3β) inhibitors are expected to be attractive therapeutic agents for the treatment of Alzheimer's disease (AD). Recently we discovered sulfoxides (S)-1 as a novel GSK-3β inhibitor having in vivo efficacy. We investigated practical asymmetric preparation methods f...

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Bibliographic Details

Published in:	Chemical and Pharmaceutical Bulletin Vol. 58; no. 9; pp. 1252 - 1254
Main Authors:	Saitoh, Morihisa, Kunitomo, Jun, Kimura, Eiji, Yamano, Toru, Itoh, Fumio, Kori, Masakuni
Format:	Journal Article
Language:	English
Published:	The Pharmaceutical Society of Japan 01-09-2010
Subjects:	Alzheimer's disease enantioselective oxidation glycogen synthase kinase 3β
Online Access:	Get full text
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