Clinical study of biapenem
Biapenem (BIPM) was administered to bacterial pneumonia in 9 cases, acute bronchitis in 2 cases, epiglottic abscess in 1 case, pyelonephritis in 1 case and hepatic abscess in 1 case. The drugs were given intravenously for 5-15 days at a dose of 150-600mg, twice per day. Clinical efficacy was excelle...
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| Published in: | CHEMOTHERAPY Vol. 42; no. Supplement4; pp. 787 - 791 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English Japanese |
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Japanese Society of Chemotherapy
1994
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| Abstract | Biapenem (BIPM) was administered to bacterial pneumonia in 9 cases, acute bronchitis in 2 cases, epiglottic abscess in 1 case, pyelonephritis in 1 case and hepatic abscess in 1 case. The drugs were given intravenously for 5-15 days at a dose of 150-600mg, twice per day. Clinical efficacy was excellent in 5 cases, good in 6 cases, fair in 1 case and excluded in 2 cases. Causative organisms were Haemophilus influenzae (1 case), Escherichia coli (1 case), Streptococcus pneumoniae (1 case), and all them were eradicated. No adverse reaction was observed. The elevated γ-GTP was seen in a patient as to abnormal laboratory finding. |
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| AbstractList | Biapenem (BIPM) was administered to bacterial pneumonia in 9 cases, acute bronchitis in 2 cases, epiglottic abscess in 1 case, pyelonephritis in 1 case and hepatic abscess in 1 case. The drugs were given intravenously for 5-15 days at a dose of 150-600mg, twice per day. Clinical efficacy was excellent in 5 cases, good in 6 cases, fair in 1 case and excluded in 2 cases. Causative organisms were Haemophilus influenzae (1 case), Escherichia coli (1 case), Streptococcus pneumoniae (1 case), and all them were eradicated. No adverse reaction was observed. The elevated γ-GTP was seen in a patient as to abnormal laboratory finding. |
| Author | Tatara, Ichiro Inoue, Touji Kono, Kenji Minamikawa, Hiromichi Takeda, Seiji Arakawa, Kikuo |
| Author_xml | – sequence: 1 fullname: Kono, Kenji organization: Second Department of Internal Medicine, School of Medicine, Fukuoka University – sequence: 2 fullname: Takeda, Seiji organization: Second Department of Internal Medicine, School of Medicine, Fukuoka University – sequence: 3 fullname: Tatara, Ichiro organization: Second Department of Internal Medicine, School of Medicine, Fukuoka University – sequence: 4 fullname: Arakawa, Kikuo organization: Second Department of Internal Medicine, School of Medicine, Fukuoka University – sequence: 5 fullname: Inoue, Touji organization: Minamikawa Seikeigeka Hospital – sequence: 6 fullname: Minamikawa, Hiromichi organization: Minamikawa Seikeigeka Hospital |
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| References | 2) Hikida M, kawashima K, Yoshida M and Mitsuhashi S: Inactivation of new carbapenem antibiotics by dehydropeptidase-I from procine and human renal cortex. J. Antimicrob Chemother 30: 129-134, 1992 1) Ubukata K, Hikida M, Yoshida M, Nishiki K, Furukawa Y, Tashiro K, Konno M and Mitsuhashi S: In vitro activity of LJC 10, 627, a new carbapenem antibiotic with high stability to dehydropeptidase-I. Antimicrob Agents Chemother. 34: 994-1000, 1990 3) Hikida M, Kawashima K, Nishiki K, Furukawa Y, Nishizawa K, Saito I and Kuwao S: Renal dehydropeptidase-I stability of LJC 10627, a new carbapenem antibiotic. Antimicrob Agents Chemother. 36: 481-483, 1992 |
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| Title | Clinical study of biapenem |
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