FUNDAMENTAL AND CLINICAL EVALUATION OF HAPA-B IN THE FIELD OF UROLOGY

• Published in: CHEMOTHERAPY Vol. 33; no. Supplement5; pp. 529 - 539
• Main Authors: ARAKAWA, SOICHI, FUJII, AKIRA, KAWABATA, GAKU, HARADA, MASUYOSHI, KATAOKA, NOBUMASA, KAMIDONO, SADAO, ISHIGAMI, JOJI, NAKANO, YASUHARU, SUGINO, MASASHI
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1985
• DOI: 10.11250/chemotherapy1953.33.Supplement5_529
• EISSN: 1884-5894
• ISSN: 0009-3165

HAPA-B, a new aminoglycoside antibiotic, was studied fundametally and clinically. 1. Antibacterial effects of HAPA-B against clinical isolates derived from urinary tracts were compared with those of GM, AMK, DKB and ASTM. HAPA-B was superior to the others in antibacterial effects against C. freundii (the peak of MICs was 1.56μg/ml), E. cloacae (1.56) and S. marcescens (1.56-3.13); against E. coil (1.56), K. pneumoniae (1.56) and indole positive Proteus (0.39), superior to the others except GM; against P. mirabilis (6.25), similar to AMK and ASTM and inferior to GM and DKB; against P. aeruginosa (6.25), similar to GM and AMK, and inferior to DKB. MIC of HAPA-B against all those strains was less than 100μg/ml. 2. HAPA-B was administered to 31 patients with complicated urinary tract infections by intramuscular injection. The effectiveness rate was 47% by doctor's evaluation. According to the criteria of UTI committee, the results were excellent in one case, moderate in 14 cases, poor in 9 cases and the effectiveness rate was 63%. Bacteriologically, bacteria was eradicated in 26 strains out of 28 and all gram negative bacteria were eradicated. No subjective and objective side effect was found. Whereas abnormal laboratory findings were observed in three cases, rise of GOT and GPT with decrease of RBC in peripheral blood, eosinophilia and elevation of BUN and S-Cr., but they returned to the normal soon.