PHARMACOKINETICS AND CLINICAL STUDIES OF CEFEPIME FOR SURGICAL INFECTION

• Published in: CHEMOTHERAPY Vol. 39; no. Supplement2; pp. 301 - 305
• Main Author: Kasano, Yasuo
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1991
• Subjects: Cefepime
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.39.Supplement2_301

The kinetic profile of cefepime (CFPM), a new cephem antibiotics, which is highly active against Gram-negative bacilli was clarified and its clinical efficacy in biliary tract infections and peritonitis was investigated. 1) When 1g of CFPM was intravenously given to patients, the blood concentration reached 44. 4μg/ml 1 hour after administration. The blood concentrations 2 and 6 hours after administration were 22.7 and 8.7μg/ml, respectively. The half-life was 1.8 hour. 2) The biliary concentration at a dose of 1g was determined in two patients with an indwelling T-tube, showing that the peak level was 17.5μg/ml. The concentration in ascitic fluid in a patient undergoing abdominal drainage showed a peak level of 127μg/ml. 3) The clinical efficacy was excellent in 2 and good in 4 cases. The isolated organisms from biliary tract infections were Escherichia coli, Klebsiella pneumoniae and Citrobacter freundii. The isolated organisms from peritonitis were not only aerobes but also anaerobes such as Bacteroides and Clostridium. All these organisms were sensitive to CFPM. Bacteria were eradicated in 2 cases. None of the patients given CFPM had side effects or abnormal laboratory data attributable to this antibiotic.