CONCENTRATION OF CEFPIROME IN TISSUES AND CLINICAL EFFICACY IN SURGICAL INFECTIONS

• Published in: CHEMOTHERAPY Vol. 39; no. Supplement1; pp. 407 - 418
• Main Authors: TANIMURA, HIROSHI, JOHATA, KIYOFUMI, YUKAWA, HIROFUMI, IWAHASHI, MAKOTO, MIZOHATA, SHIZUMA, MINAMI, MITSUAKI, YAMAMOTO, SHINJI, SHIMADA, KOHSUKE, UEDA, KOHSHIN, INABU, SEIKI, NAKAYAMA, HITOSHI, KOBAYASHI, YASUTO, EGAWA, HIROSHI, TSUHADA, KENJI, OKA, SUMIKAZU
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1991
• Subjects: Cefpirome
• DOI: 10.11250/chemotherapy1953.39.Supplement1_407
• EISSN: 1884-5894
• ISSN: 0009-3165

Clinical studies on cefpirome (CPR), a new cephem antibiotic, were investigated in 39 cases of surgical infections. 1. Blood levels were determined by HPLC and bioassay method after intravenous administration of CPR 1 g. The mean levels were 71.7±19.9μg/ml immediately after drip infusion, and 9.0 ±4.6μg/ml after 6 h. Maximum levels in urine were 1300-3230 μg/ml at 1-2 h. 2. Maximum levels in several human tissues, such as the gallbladder, pancreas, spleen, thyroid, subcutaneous fat, peritoneum and omentum, were 44.6, 15.9, 11.4, 9.31, 14.1, 22.8 and 11.1 μg/g at about 4 h after intravenous administration of CPR 1 g, respectively. 3.As to transfer of CPR into bile in patients with an indwelling T-tube, the maximum level was dose-dependedly 27.9μg/ml and 55.3 μg/ml 2 h after administration of CPR 1 g or 2 g. 4.In two patients with gastric cancer received intravenously CPR 1 g, peak levels of CPR in ascitic fluid were 13.9 and 22.5μg/ml at 3 h after drip infusion on the first postoperative day. 5.The clinical result in 15 patients, (2 with diffuse peritonitis, 1 with abdominal abscess, 8 with cholecystitis, and 4 with cholangitis), was excellent in 1, good in 10, fair in 3 and unknown in 1, with a clinical efficacy rate being 78.6%. As abnormal laboratory findings, elevated BUN and creatinine in only one case were noted.