β2-Adrenergic Receptor Stimulation Improves Endothelial Progenitor Cell–Mediated Ischemic Neoangiogenesis

RATIONALE:Endothelial progenitor cells (EPCs) are present in the systemic circulation and home to sites of ischemic injury where they promote neoangiogenesis. β2-Adrenergic receptor (β2AR) plays a critical role in vascular tone regulation and neoangiogenesis. OBJECTIVE:We aimed to evaluate the role...

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Bibliographic Details
Published in:	Circulation research Vol. 112; no. 7; pp. 1026 - 1034
Main Authors:	Galasso, Gennaro, De Rosa, Roberta, Ciccarelli, Michele, Sorriento, Daniela, Del Giudice, Carmine, Strisciuglio, Teresa, De Biase, Chiara, Luciano, Rossella, Piccolo, Raffaele, Pierri, Adele, Di Gioia, Giuseppe, Prevete, Nella, Trimarco, Bruno, Piscione, Federico, Iaccarino, Guido
Format:	Journal Article
Language:	English
Published:	United States American Heart Association, Inc 29-03-2013
Subjects:	Adrenergic beta-Agonists - pharmacology Animals Cell Differentiation - drug effects Cell Differentiation - physiology Cell Movement - drug effects Cell Movement - physiology Cell Proliferation - drug effects Cells, Cultured Chronic Disease Disease Models, Animal Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Hematopoietic Stem Cells - physiology Hindlimb - blood supply Ischemia - drug therapy Ischemia - pathology Ischemia - physiopathology Isoproterenol - pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Rats Rats, Inbred WKY Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - metabolism
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