P2Y2 receptors activate neuroprotective mechanisms in astrocytic cells

Mechanical or ischemic trauma to the CNS causes the release of nucleotides and other neurotransmitters into the extracellular space. Nucleotides can activate nucleotide receptors that modulate the expression of genes implicated in cellular adaptive responses. In this investigation, we used human 132...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 91; no. 1; pp. 119 - 132
Main Authors:	Chorna, Nataliya E., Santiago‐Pérez, Laura I., Erb, Laurie, Seye, Cheikh I., Neary, Joseph T., Sun, Grace Y., Weisman, Gary A., González, Fernando A.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01-10-2004 Blackwell
Subjects:	astrocytes Biological and medical sciences Fundamental and applied biological sciences. Psychology gene expression Isolated neuron and nerve. Neuroglia P2Y2 nucleotide receptor purinergic signaling Vertebrates: nervous system and sense organs Neuroprotection Signal transduction P2Y2 nucleotide receptor purinergic signaling Cell line P2Y2 purinergic receptor Neuroglia Astrocyte astrocytes Gene expression In vitro
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