Successful early treatment in a case of Cogan's syndrome

• Published in: Nihon Rinshō Menʾeki Gakkai kaishi Vol. 35; no. 1; p. 92
• Main Authors: Tsuno, Hirotaka, Takahashi, Yuko, Yoshida, Yuji, Arai, Naotoshi, Nakamura, Yousuke, Yashiro, Seiko, Makizumi, Masami, Yamashita, Hiroyuki, Kaneko, Hiroshi, Kano, Toshikazu, Mimori, Akio
• Format: Journal Article
• Language: Japanese
• Published: Japan 2012
• Subjects: Cogan Syndrome - diagnostic imaging; Cogan Syndrome - physiopathology; Cogan Syndrome - therapy; Early Medical Intervention; Humans; Male; Middle Aged; Multimodal Imaging; Positron-Emission Tomography; Tomography, X-Ray Computed
• DOI: 10.2177/jsci.35.92
• EISSN: 1349-7413

We report a 53-year-old male with Cogan's syndrome. He was admitted to our hospital because of a fever of 2-weeks duration, blurred vision for 10 days, hypoacusis, and numbness of the left hand for 3 days. In addition to uveitis, hypoacusis, and aseptic meningitis, multiple mononeuropathy was diagnosed based on a nerve conduction study. Furthermore, positron emission tomography/computed tomography (PET/CT) revealed diffuse aortitis. Accordingly, the patient was diagnosed with Cogan's syndrome. After starting steroid-pulse therapy followed by 1 mg oral prednisolone/kg/day, the uveitis and hypoacusis improved immediately, while the peripheral neuropathy persisted until effectively treated with intravenous gamma globulin therapy. Prompt steroid therapy for Cogan's syndrome based on a diagnosis made using PET/CT prevented progression of the hypoacusis.