LABORATORY AND CLINICAL STUDIES ON CEPHRADINE

• Published in: CHEMOTHERAPY Vol. 23; no. 1; pp. 369 - 378
• Main Authors: BAN, YOSHIHITO, KAWADA, YUKIMICHI, NISHIURA, TSUNEO
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1975
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.23.369

Basic and clinical studies were carried out on cephradine, a new semisynthetic cephalosporin. 1) Susceptibilities to cephradine and cephalexin were tested on 146 strains newly isolated from genitourinary tract infections. The results indicated that antibacterial activities and sensitivity distributions to cephradine were almost the same as those to cephalexin. 2) Bacterial growth rate in a medium containing cephradine or cephalexin was observed by means of a biophotometer (BIO-LOG 11). The influences were investigated about the antibiotic concentration, inoculum size of organism (E. coli NIHT JC-2), morphological change, and MIC after the experiments. The growth rates in the presence of cephradine were almost the same to those in the presence of cephalexin in various experiments. The MIC's after experiments were not greatly changed from that of before those cultures. Both antibiotics gave similar results each other in the biophotometric studies, except that cephradine seemed to have a tendency to promote filamentation than cephalexin. 3) Thirty-one patients with genitourinary infections were treated with cephradine at a daily dose of 1 g for 3 or 4 days, and the therapeutic results were evaluated both clinically and bacteriologically. All the acute infections (16 cases) responded well to the drug, and good results were obtained in 11 out of 15 chronic cases (73%). 4) No side effect was observed throughout the course of the treatment of cephradine, except for nausea only in one case.