Urinary fibrin-fibrinogen degration products in the renal diseases

• Published in: The Japanese Journal of Nephrology Vol. 19; no. 3; pp. 139 - 149
• Main Authors: TAURA, Koichi, FUKUSHIMA, Katsuhiko, SHINZATO, Ken, HARADA, Takashi, OGATA, Hirofumi, FUJIMATSH, Shinichiro, SHO, Tadaharu, HORITA, Satoru, HARA, Kohei, FUJITA, Senji, ITOGA, Takashi, KAKIMOTO, Shigeru, KONDO, Atsushi, MATSUKUMA, Genichiro, FUNAKOSHI, Eiichi
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Nephrology 1977
• ISSN: 0385-2385; 1884-0728
• DOI: 10.14842/jpnjnephrol1959.19.139

The urinary excretion of fibrin-fibrinogen degradation products(FDP) was examined by method of haemagglutination-inhibition test in 84 patients with the renal diseases. The subjects consisted of 51 cases of chronic glomerulo-nephritis, 8 cases of chronic renal failure, and 25 cases of nephrotic syndrome.1. Urinary FDP were found in 20% of patients with chronic glomerulonephritis and in 50% of patients with chronic renal failure. In contrast, urinary FDP most commonly presented in nephrotic patients witn severe glome-rular lesions, but were not found in any of 6 patients of minimal lesions.2. The urinary FDP excretion was correlated with the grade of microhematuria.3, Urinary FDP excretion changenable to renal pathologic process was not paralled to the levels of serum FDP.4. Both urinary FDP and intraglomerular fibrin daposits judged oy immunofuorescense were found in nephrotic patients of proliferative or sclerosing lesions, but not in that of minimal lesions. However there is a little correlation betweeen the extent of intragomerular fibrin deposits and urinary FDP excretion in nephrotic patients of membranous or combined lesions and in the paaients. of chronic glomerulonephritis.5. In nephrotic syndrome, urinary FDP was variable to selectivity of proteinuria than the quantity of urine protein. Among 11 cases of nephrotic patients with urine FDP excretion, 10 cases (91%) had α2-MG inheir urine, and 9 cases (82%) had high levels of trans RIgG (0.2<).6. No significant correlation was recognized between the urinary FDP excretion and plasma fibrinolytic activity or urine activator activity.