STUDIES ON THE ORIGIN OF SERUM MUCOPROTEIN PRODUCTION-STUDIES PERTAINING TO INCREASED MUCOPROTEIN IN MALIGNANT TUMORS

• Published in: Gann Vol. 48; no. 3; pp. 305 - 314
• Main Authors: WADA, TAKEO, OHARA, HIROMICHI, SASAKI, TADAO, NAKAJIMA, JIRO, YACHI, AKIRA
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Cancer Association 01-10-1957
• Subjects: Blood Proteins; Mucoproteins; Neoplasms - metabolism; Old Medline; BLOOD PROTEINS; NEOPLASMS/metabolism
• ISSN: 0016-450X
• DOI: 10.20772/cancersci1907.48.3_305

1) It was concluded that physiologic Mp is produced by the liver, from the fact that Mp content of posthepatic blood was higher than that of prehepatic blood, and serum Mp content decreased in the presence of both clinical and experimental liver damages. 2) Physiologic Mp level was assumed to be metabolized by the phagocytic function of RES, owing to the fact that Mp level increased with lowered phagocytic activity of the RES, and decreased with acceleration of its activity. 3) On the other hand, it was postulated that the increased serum Mp found in malignant tumor was liberated from the tumor tissue itself, by comparing the Mp content of afferent and efferent blood. 4) Further discussion was made concerning the existence of another source (perhaps in the liver) of Mp induced indirectly by the presence of the malignant tumor in addition to the Mp as produced by the tumor tissue, and that the Mp produced by the tumor tissue itself may be connected with the carrier of cancer toxin.