Anorexia nervosa with neutropenia--response of neutrophils to G-CSF

• Published in: Rinshō ketsueki Vol. 33; no. 3; p. 328
• Main Authors: Muraki, Y, Kobayashi, T, Kojima, H, Shibuya, A, Nagasawa, T, Abe, T, Mori, N
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-03-1992
• Subjects: Anorexia Nervosa - blood; Anorexia Nervosa - therapy; Female; Granulocyte Colony-Stimulating Factor - therapeutic use; Humans; Leukocyte Count; Middle Aged; Neutropenia - therapy; Neutrophils - physiology
• ISSN: 0485-1439
• DOI: 10.11406/rinketsu.33.328

A 50-year-old woman with anorexia nervosa was admitted for evaluation of neutropenia (WBC 1,600/microliters). Her bone marrow was gelatinous, and myeloid cells had decreased. Homogeneous substance deposited in the marrow, stained by alcian blue (pH 2.5), indicative of acid mucopolysaccharides. CFU-G and CFU-GM were decreased in number and myeloid pool in the bone marrow also decreased. Anti-neutrophilic antibody was negative. Neutropenia may be related to myeloid hypoplasia, due to increase of acid mucopolysaccharides replacing adipose cells in the bone marrow under long-term mal-nutritional state. Neutrophils markedly increased by administration of rhG-CSF 5.0 micrograms/kg/day for 14 days without the first peak. Serum G-CSF level did not increase (less than 60 pg/ml). It is effective to administer G-CSF to anorexia nervosa with neutropenia.